HDAC8 Recombinant Protein

Source : Escherichia Coli. HDAC8 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 383 amino acids (1-377) and having a molecular mass of 42.6kDa.HDAC8 is fused to a 6 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques. Histone deacetylase 8 (HDAC8) is a member of the class 1 of the histone deacetylase/acuc/apha family. HDAC8 is biologically involved in skull morphogenesis and metabolic control of the ERR-alpha/PGC1-alpha transcriptional complex. Histones play a key role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation modifies chromosome structure and affects transcription factor access to DNA.

Product Specifications

Product Name Alternative

Histone deacetylase 8||HD8||HDAC8||HDACL1||CDA07||RPD3.

Purification

Greater than 80% as determined by SDS-PAGE.

Components

The HDAC8 solution (0.25mg/mL) contains 20mM Tris-HCl buffer (pH8.0), 20% glycerol, 0.1M NaCl and 1mM DTT.

Storage Conditions

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA) .Avoid multiple freeze-thaw cycles.