SARS-CoV-2 Spike S1 D614G Stable Trimer Recombinant His Protein

Full-length soluble SARS-CoV-2 Spike protein (aa 16-1213) including a foldon trimerization motif, mutated Furin recognition site (R682S, R685S) and two stabilizing mutations (K986P and V987P) is fused at the C-terminus to a His-tag. Source: Expressed in HEK-293 cells. Reconstitution: Reconstitute with 250μl endotoxin-free water. Concentration: 0.2mg/ml after reconstitution. Background: The spike S1 protein of SARS-CoV-2 attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2) . A defined receptor-binding domain (RBD) on S1 mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.