PSI-6130

PSI-6130 is a potent and selective inhibitor of HCV NS5B polymerase, and inhibits HCV replication with a mean IC50 of 0.6 μM.

Product Specifications

CAS Number

[817204-33-4]

Product Name Alternative

R 1656

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

HCV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/PSI-6130.html

Purity

99.90

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C1N=C(C=CN1[C@@H]([C@@](C)([C@@H]2O)F)O[C@@H]2CO)N

Molecular Formula

C10H14FN3O4

Molecular Weight

259.24

Precautions

H302, H315, H319, H335

References & Citations

[1]Ali S, et al. Selected replicon variants with low-level in vitro resistance to the hepatitis C virus NS5B polymerase inhibitor PSI-6130 lack cross-resistance with R1479. Antimicrob Agents Chemother. 2008 Dec;52 (12) :4356-69.|[2]Ma H, et al. Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor beta-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine (PSI-6130) and identification of a novel active 5'-triphosphate species. J Biol Chem. 2007 Oct 12;282 (41) :29812-20. Epub 2007 Aug 13.