Anti-MDR3 Monoclonal Antibody (Clone:IHC621)
Multidrug Resistance 3 (MDR3), also known as ATP Binding Cassette Subfamily B Member 4 (ABCB4), is a membrane-associated protein belonging to the superfamily of ATP-binding cassette transporters. MDR3 is an energy-dependent phospholipid efflux translocator that mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte, and also acts as a positive regulator of biliary lipid secretion. Defects in MDR3 are associated with progressive familial intrahepatic cholestasis type 3 and gallbladder disease type 1. Co-overexpression of MDR3 and MRP1 has been documented as correlating with blastemal subtype and high-risk prognosis of Wilms' tumor patients.
Product Specifications
Product Name Alternative
Phosphatidylcholine translocator ABCB4, ATP-binding cassette sub-family B member 4, Multidrug resistance protein 3, P-glycoprotein 3
Gene Name
ABCB4
Gene ID
5244
UniProt
P21439
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Clone
IHC621
Applications
IHC
Purification
Protein A/G Chromatography
Format
Purified
Shipping Conditions
Blue Ice / Ice Pack
Storage Conditions
Store at 2°C - 8°C.
Applications Notes
Recommended dilutions: Immunohistochemical analysis: 1:100 - 1:200. However, this need to be optimized based on the research applications.
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
