Anti-MLH1 Monoclonal Antibody (Clone:IHC409)
MutL Homolog 1 (MLH1) is a protein involved in the mismatch-repair pathway. This protein is commonly associated with hereditary non-polyposis colorectal cancer, as the MLH1 gene is frequently mutated in patients with this cancer. Use of Anti-MLH1 is optimized when paired in an IHC panel with MSH6, MSH2, and PMS2. Anti-MLH1 is useful in the detection of MLH1 in a number of normal and neoplastic tissues, and for identifying a loss of MLH1 in tumors that are microsatellite-unstable.
Product Specifications
Product Name Alternative
MLH1||COCA2
Gene Name
MLH1
Gene ID
4292
UniProt
P40692
Host
Mouse
Reactivity
Human
Immunogen
Recombinant Human MLH1
Clonality
Monoclonal
Clone
IHC409
Applications
IHC
Purification
Protein A/G Chromatography
Format
Purified
Components
Tris Buffer, pH 7.3 - 7.7, with 1% BSA and
Storage Conditions
Store at 2°C - 8°C. Do not freeze.
Applications Notes
Recommended dilutions: Immunohistochemical analysis: 1:100 - 1:200. However, this need to be optimized based on the research applications.
Isotype
Mouse IgG2a
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