Anti-CNTF Polyclonal Antibody

Ciliary neurotrophic factor (CNTF) is a potent polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes survival, neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The CNTF gene is located on chromosome 11, as determined using human-hamster somatic cell hybrids. The CNTF protein is highly conserved in evolution. The amino acid (aa) sequences of rat and rabbit CNTF translated from cDNAs display approx. 85% homology with the deduced aa sequence encoding human CNTF. CNTF induces weight loss and improves glucose tolerance in humans and rodents. CNTF is thought to act centrally by inducing hypothalamic neurogenesis to modulate food intake and peripherally by altering hepatic gene expression, in a manner similar to that of leptin.

Product Specifications

Product Name Alternative

Ciliary neurotrophic factor; CNTF; CNTF

Gene Name

CNTF

Gene ID

1270

UniProt

P26441

Host

Rabbit

Reactivity

Human

Immunogen

E.coli-derived Human CNTF recombinant protein (Position: A2-M200) . Human CNTF shares 83% and 84% amino acid (aa) sequence identity with Mouse and Rat CNTF, respectively.

Target Antigen

Ciliary neurotrophic factor

Clonality

Polyclonal

Applications

WB, IHC-P

Purification

Immunogen affinity purified.

Components

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3. Reconstitute : Add 0.2ml of distilled water will yield a concentration of 500ug/mL.

Storage Conditions

At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.