Anti-PKB alpha Monoclonal Antibody (Clone: PKB-175)

PKB alpha also knows as V-AKT murine thymoma vial oncogene homolog 1 (ATK1) . AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and is abrogated by mutations in the pleckstrin homology domain of AKT1. AKT1 gene is mapped to chromosome 14q32.3. Akt1/protein kinase B-alpha is critical for ischemic and VEGF-mediated angiogenesis. Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo.

Product Specifications

Product Name Alternative

RAC-alpha serine/threonine-protein kinase; 2.7.11.1; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; RAC-PK-alpha; Akt1

Gene Name

Akt1

Gene ID

24185

UniProt

P47196

Host

Mouse

Reactivity

Human

Immunogen

Synthetic peptide corresponding to amino acids 461-477 of human PKB alpha/Akt1, conjugated to KLH.

Target Antigen

RAC-alpha serine/threonine-protein kinase

Clonality

Monoclonal

Clone

PKB-175

Applications

Purification

Ascites

Components

Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative. Reconstitute : Add 1ml of PBS buffer will yield a concentration of 100ug/mL.

Storage Conditions

At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.