Anti-PKB alpha Monoclonal Antibody (Clone: PKB-175)

PKB alpha also knows as V-AKT murine thymoma vial oncogene homolog 1 (ATK1) . AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and is abrogated by mutations in the pleckstrin homology domain of AKT1. AKT1 gene is mapped to chromosome 14q32.3. Akt1/protein kinase B-alpha is critical for ischemic and VEGF-mediated angiogenesis. Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo.