Anti-p16INK4a/CDKN2 Monoclonal Antibody (Clone: DCS-50)
P16 (INK4A), also known as cyclin-dependent kinase inhibitor 2A (CDKN2A), or multiple tumor suppressor 1 (MTS1) . The p16 gene (CDKN2A) was mapped to 9p21. The p16 gene encodes a negative regulator of the cell cycle. CDKN2 plays an important role during tumorigenesis or tumor progression in a significant proportion of pancreatic adenocarcinomas. Germ-line mutations in the CDKN2A tumor-suppressor gene have been linked to the development of melanoma in some families with inherited melanoma.
Product Specifications
Product Name Alternative
Cyclin-dependent kinase inhibitor 2A ; Cyclin-dependent kinase 4 inhibitor A; CDK4I; p16-INK4a; p16; p16-INK4; Cdkn2a ; P16ink4a
Gene Name
Cdkn2a
Gene ID
25163
UniProt
Q9R0Z3
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human p16 protein.
Target Antigen
Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3
Clonality
Monoclonal
Clone
DCS-50
Applications
WB, IHC-F, ICC
Purification
Ascites
Components
Storage Conditions
Applications Notes
Western blot : 0.5-1μg/ml; Immunohistochemistry (Frozen Section) : 1-2μg/ml; Immunocytochemistry : 1μg/ml
Isotype
Mouse IgG1
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