Anti-p16INK4a/CDKN2 Monoclonal Antibody (Clone: DCS-50)

P16 (INK4A), also known as cyclin-dependent kinase inhibitor 2A (CDKN2A), or multiple tumor suppressor 1 (MTS1) . The p16 gene (CDKN2A) was mapped to 9p21. The p16 gene encodes a negative regulator of the cell cycle. CDKN2 plays an important role during tumorigenesis or tumor progression in a significant proportion of pancreatic adenocarcinomas. Germ-line mutations in the CDKN2A tumor-suppressor gene have been linked to the development of melanoma in some families with inherited melanoma.

Product Specifications

Product Name Alternative

Cyclin-dependent kinase inhibitor 2A ; Cyclin-dependent kinase 4 inhibitor A; CDK4I; p16-INK4a; p16; p16-INK4; Cdkn2a ; P16ink4a

Gene Name

Cdkn2a

Gene ID

25163

UniProt

Q9R0Z3

Host

Mouse

Reactivity

Human

Immunogen

Recombinant human p16 protein.

Target Antigen

Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3

Clonality

Monoclonal

Clone

DCS-50

Applications

WB, IHC-F, ICC

Purification

Ascites

Components

Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative. Reconstitute : Add 1ml of PBS buffer will yield a concentration of 100ug/mL.

Storage Conditions

At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.