Anti-NF68 Monoclonal Antibody (Clone: NR4)

Neurofilaments are composed of 3 neuron-specific proteins with apparent molecular masses of 68 kD (NFL), 125 kD (NFM) and 200 kD (NFH) on SDS-gel electrophoresis. And they have a role in the maturation of regenerating myelinated axons. Neurofilament 68 (NF68), also called Neurofilament Protein, Light Chain (NFL) . It is one of the most abundant cytoskeletal components of the neuron. Mutations in this gene were reported as a cause for autosomal dominant Charcot-Marie-Tooth type 2E (CMT2E) linked to chromosome 8p21. NFL was identified repeatedly in both screenings and found to interact with Myotubularin-related 2 gene, MTMR2 in both Schwann cells and neurons.

Product Specifications

Product Name Alternative

Neurofilament light polypeptide; NF-L; 68 kDa neurofilament protein; Neurofilament triplet L protein; Nefl; Nf68, Nfl

Gene Name

Nefl

Gene ID

83613

UniProt

P19527

Host

Mouse

Reactivity

Human

Immunogen

Pig spinal cord.

Target Antigen

Neurofilament light polypeptide

Clonality

Monoclonal

Clone

NR4

Applications

WB, IHC-P, IHC-F

Purification

Ascites

Components

Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative. Reconstitute : Add 1ml of PBS buffer will yield a concentration of 100ug/mL.

Storage Conditions

At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.