Anti-P-Glycoprotein (MDR) Monoclonal Antibody (Clone: F4)

P-Glycoprotein, , also known as Multidrug Resistance 1 (MDR1), is one of the ATP-binding cassette transporters family. P-glycoprotein-1 is involved in the transport of 3 of these protease inhibitors in vitro. MDR1 gene is mapped to the 7q21.1 by in situ hybridization. The MDR1 gene product, P-glycoprotein, mediates the transport of the cardiac glycoside, digoxin.

Product Specifications

Product Name Alternative

Multidrug resistance protein 1A; 3.6.3.44; ATP-binding cassette sub-family B member 1A; MDR1A; Multidrug resistance protein 3; P-glycoprotein 3; Abcb1a; Abcb4, Mdr1a, Mdr3, Pgy-3, Pgy3

Gene Name

ABCB1

Gene ID

5243

UniProt

P08183

Host

Mouse

Reactivity

Human

Immunogen

Mixture of human and hamster drug-resistant whole cells and crude plasma membranes.

Target Antigen

Multidrug resistance protein 1

Clonality

Monoclonal

Clone

Applications

WB, IHC-P, IHC-F, ICC

Purification

Ascites

Components

Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative. Reconstitute : Add 1ml of PBS buffer will yield a concentration of 100ug/mL.

Storage Conditions

At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.

Applications Notes

Western blot : 0.5-1μg/ml; Immunohistochemistry (Paraffin-embedded Section) : 1-2μg/ml; Immunohistochemistry (Frozen Section) : 1-2μg/ml; Immunocytochemistry : 1μg/ml