Anti-HSP70 Monoclonal Antibody (Clone: BRM-22)

Heat-shock proteins, or stress proteins, are expressed in response to heat shock and a variety of other stress stimuli including oxidative free radicals and toxic metal ions. Sargent et al. identified a duplicated HSP70 locus in the class III region of the major histocompatibility complex on 6p21.3. A duplicated locus encoding the major heat shock-induced protein HSP70 is located in the major histocompatibility complex (MHC) class III region 92 kilobases (kb) telomeric to the C2 gene. The 70-kd mammalian heat shock proteins are structurally and functionally related to the uncoating protein that releases clathrin triskelia from coated vesicles.

Product Specifications

Product Name Alternative

Heat shock 70 kDa protein 1B; Heat shock 70 kDa protein 1; HSP70.1; Hspa1b; Hcp70.1, Hsp70-1, Hsp70a1, Hspa1

Gene Name

Hspa1b

Gene ID

15511

UniProt

P17879

Host

Mouse

Reactivity

Human

Immunogen

HSP70 isolated from bovine brain.

Target Antigen

Heat shock 70 kDa protein 1A/1B

Clonality

Monoclonal

Clone

BRM-22

Applications

WB, IHC-P, IHC-F

Purification

Ascites

Components

Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative. Reconstitute : Add 1ml of PBS buffer will yield a concentration of 100ug/mL.

Storage Conditions

At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.