Anti-CD3 Monoclonal Antibody (Clone: CA-3)

The alpha-beta heterodimeric T-cell antigen receptor binds antigen in association with major histocompatibility complex proteins on host cell surfaces. These 2 disulfide-linked glycoproteins, TCRA and TCRB are associated on T-cell surfaces with a complex of proteins called CD3 (formerly T3) . Human CD3 consists of at least 4 proteins: gamma, delta, epsilon, and zeta. The CD3-gamma/CD3-delta gene pair is within 300 kb of the CD3-epsilon gene and therefore these genes form a tightly linked cluster on 11q23. The clustering may be significant in terms of their simultaneous activations during T-cell development.

Product Specifications

Product Name Alternative

CD3 antigen, epsilon polypeptide (Predicted) ; Protein Cd3e ; Cd3e ; Cd3e_predicted ; rCG_58471

Gene Name

Cd3e

Gene ID

315609

UniProt

D4A5M2

Host

Mouse

Reactivity

Human

Immunogen

Human thymocytes followed by Sezary T cells.

Target Antigen

T-cell surface glycoprotein CD3 epsilon chain

Clonality

Monoclonal

Clone

CA-3

Applications

IHC-F

Purification

Ascites

Components

Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative. Reconstitute : Add 1ml of PBS buffer will yield a concentration of 100ug/mL.

Storage Conditions

At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.