Anti-GITR / Tnfrsf18 (Mouse) Monoclonal Antibody (Clone: DTA-1)

GITR (glucocorticoid-induced TNFR-related gene) is a member of the TNF-alphaeceptor superfamily, also known as TNFRSF18. It is expressed at low levels on resting T lymphocytes and at high levels on CD25+CD4+Tregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to aμgment T cell activation, proliferation, cytokine production as well as MAPKs and NF-B activation, and abrogate the inhibitory function ofCD25+CD4+Tregs. In vivoactivation of GITR causes development of autoimmune diseases and restores the suppressed immune response.