Anti-CD47 / IAP (Integrin Associated Protein) Monoclonal Antibody (Clone: B6H12.2)
This antibody reacts with Ig domain of CD47 protein. It has been shown to inhibit polymorphonuclear neutrophil (PMN) transmigration across cell monolayers and matrix. CD47, originally named integrin-associated protein (IAP), is a 50kDa protein containing five membrane-spanning sequences and a short cytoplasmic tail. CD47 plays a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. It is important in memory formation and synaptic plasticity in the hippocampus. CD47 may play a role in membrane transport and/or integrin dependent signal transduction.
Product Specifications
Product Name Alternative
Gene Name
CD47
Gene ID
961
UniProt
Q08722
Host
Mouse
Reactivity
Human, Mouse
Immunogen
Intact CD47 Purified from placenta
Clonality
Monoclonal
Clone
B6H12.2
Applications
Functional Assay, WB, FACS, IF
Components
Storage Conditions
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.
Applications Notes
Functional Studies (Order Ab without Azide) ; Western Blot (1-2ug/ml) ; Flow Cytometry (1-2ug/million cells) ; Immunofluorescence (1-2ug/ml)
Isotype
Mouse IgG1, kappa
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