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Anti-CD28 Monoclonal Antibody (Clone: C28/76)

Recognizes a glycoprotein of 44-88kDa, which is identified as CD28. It is the critical T-cell co-stimulatory receptor which provides to the cell the important second activation signal by binding CD80 and CD86 that are expressed by antigen presenting cells. Besides its co-stimulation role, CD28 functions in preventing T-cells from anergic hyporesponsive state or from undergoing premature apoptotic cell death. CD28 is also expressed on human fetal NK cells and some NK cell lines, whereas on murine NK cells the CD28 expression is much broader.

Product Specifications

Product Name Alternative

T-cell-specific surface glycoprotein CD28; Tp44

Gene Name

CD28

Gene ID

940

UniProt

P10747

Host

Mouse

Reactivity

Human

Immunogen

Recombinant human CD28 protein

Clonality

Monoclonal

Clone

C28/76

Applications

FACS, Functional Assay

Components

200 μg/mL of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/mL.

Storage Conditions

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.

Applications Notes

Flow Cytometry (1-2ug/million cells) ; , Functional Studies (Order Ab without BSA & Azide) ;

Isotype

Mouse IgG1, kappa

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