Anti-CD28 Monoclonal Antibody (Clone: 204.12)
Recognizes a glycoprotein of 44-88kDa, which is identified as CD28. It is the critical T-cell co-stimulatory receptor which provides to the cell the important second activation signal by binding CD80 and CD86 that are expressed by antigen presenting cells. Besides its co-stimulation role, CD28 functions in preventing T-cells from anergic hyporesponsive state or from undergoing premature apoptotic cell death. CD28 is also expressed on human fetal NK cells and some NK cell lines, whereas on murine NK cells the CD28 expression is much broader.
Product Specifications
Product Name Alternative
T-cell-specific surface glycoprotein CD28; Tp44
Gene Name
CD28
Gene ID
940
UniProt
P10747
Host
Mouse
Reactivity
Human, Mouse
Immunogen
Stimulated human leucocytes
Clonality
Monoclonal
Clone
204.12
Applications
FACS, IF, Functional Assay
Components
Storage Conditions
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.
Applications Notes
Flow Cytometry (1-2ug/million cells) ; Immunofluorescence (1-2ug/ml) Functional Studies (Order Ab without BSA & Azide)
Isotype
Mouse IgG2a, kappa
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