Anti-CD3e (T-Cell Marker) Monoclonal Antibody (Clone: CRIS-7)
Recognizes the epsilon-chain of CD3, which consists of five different polypeptide chains (designated as gamma, delta, epsilon, zeta, and eta) with MW ranging from 16-28kDa. The CD3 complex is closely associated at the lymphocyte cell surface with the T cell antigen receptor (TCR) . Reportedly, CD3 complex is involved in signal transduction to the T cell interior following antigen recognition. The CD3 antigen is first detectable in early thymocytes and probably represents one of the earliest signs of commitment to the T cell lineage. In cortical thymocytes, CD3 is predominantly intra-cytoplasmic. However, in medullary thymocytes, it appears on the T cell surface. CD3 antigen is a highly specific marker for T cells, and is present in majority of T cell neoplasms.
Product Specifications
Product Name Alternative
Gene Name
CD3E
Gene ID
916
UniProt
P07766
Host
Mouse
Reactivity
Human
Immunogen
Stimulated human leukocytes
Clonality
Monoclonal
Clone
CRIS-7
Applications
FACS, IF
Components
Storage Conditions
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.
Applications Notes
Induce T cell activation and proliferation (Order Ab without Azide) ; , Flow Cytometry (1-2ug/million cells) ; , Immunofluorescence (1-2ug/ml) ;
Isotype
Mouse IgG2a, kappa
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