Anti-CD2 / Lymphocyte Function Antigen 2 (LFA-2) Monoclonal Antibody (Clone: 1E7E8.G4)
CD2 interacts throμgh its amino-terminal domain with the extracellular domain of CD58 (also designated CD2 ligand) to mediate cell adhesion. CD2/CD58 binding can enhance antigen-specific T cell activation. CD2 is a transmembrane glycoprotein that is expressed on peripheral blood T lymphocytes, NK cells and thymocytes. CD58 is a heavily glycosylated protein with a broad tissue distribution in hematopoietic and other cells, including endothelium. Interaction between CD2 and its counter receptor LFA3 (CD58) on opposing cells optimizes immune system recognition, thereby facilitating communication between helper T lymphocytes and antigen-presenting cells, as well as between cytolytic effectors and target cells.
Product Specifications
Product Name Alternative
Gene Name
CD2
Gene ID
914
UniProt
P06729
Host
Mouse
Reactivity
Human
Immunogen
Human Thymocytes/Sezary T cells
Clonality
Monoclonal
Clone
1E7E8.G4
Applications
Functional Assay, FACS, IF, WB
Components
Storage Conditions
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.
Applications Notes
Functional Studies (Order Ab without Azide) ; , Flow Cytometry (1-2ug/million cells) ; Immunofluorescence (1-2ug/ml) ; , Western Blot (1-2ug/ml) ;
Isotype
Mouse IgG2a, kappa
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