Anti-PD-L2 / PDCD1LG2 / CD273 Monoclonal Antibody (Clone: PDL2/2676)

Recognizes a protein of about 31kDa, which is identified as PD-L2 (same as PDCD1LG2) . Engagement of CD28 by B7-1 (CD80) or B7-2 (CD86) in the presence of antigen promotes T cell proliferation, cytokine production, differentiation of effector T cells and the induction of Bcl-x, a promoter of T cell survival. Conversely, engagement of CTLA4 by B7-1 or B7-2 may inhibit proliferation and IL-2 production. PD-L2 does not bind CD28, cytotoxic T lymphocyte A4 or ICOS (inducible co-stimulator) . The constitutive expression of PD-L1 and PD-L2 on parenchymal cells of heart, lung and kidney sμggests that the Pdcd-1-Pdcd-L system could provide unique negative signaling to help prevent autoimmune disease.

Product Specifications

Product Name Alternative

B7 dendritic cell molecule; B7-DC; B7DC; Btdc; Butyrophilin B7DC; CD273; PD-L2; PDCD1L2; PDCD1LG2; PDL2; Programmed death ligand 2

Gene Name

PDCD1LG2

Gene ID

80380

UniProt

Q9Q51

Host

Mouse

Reactivity

Human

Immunogen

Recombinant fragment (around aa 27-220) of human PD-L2 protein (exact sequence is proprietary)

Clonality

Monoclonal

Clone

PDL2/2676

Applications

ELISA, FACS, IF, WB

Components

200 μg/mL of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/mL.

Storage Conditions

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.

Applications Notes

ELISA (For coating, order antibody without BSA) ; , Flow Cytometry (1-2ug/million cells) ; , Immunofluorescence (1-2ug/ml) ; , Western Blot (1-2ug/ml)