Anti-ZAP70 (Chronic Lymphocytic Leukemia Marker) Monoclonal Antibody (Clone: ZAP70/2035)
ZAP70 is a 70kDa protein tyrosine kinase found in T-cells and natural killer cells.Control of this protein translation is via the IgVH gene. ZAP70 protein is expressed in leukemic cells of approximately 25% of chronic lymphocytic leukemia (CLL) cases as well.Anti-ZAP70 expression is an excellent surrogate marker for the distinction between the Ig-mutated (anti-ZAP70 negative) and Ig-unmutated (anti-ZAP70 positive) CLL subtypes and can identify patient groups with divergent clinical courses. The anti-ZAP70 positive Ig-unmutated CLL cases have been shown to have a poorer prognosis.
Product Specifications
Product Name Alternative
Selective T cell defect; SRK; STD; Syk-related tyrosine kinase; Tyrosine-protein kinase ZAP-70; TZK; Zeta chain associated protein kinase 70kDa
Gene Name
ZAP70
Gene ID
7535
UniProt
P43403
Host
Mouse
Reactivity
Human
Immunogen
Recombinant fragment of human ZAP70 protein (around aa 247-382) (exact sequence is proprietary)
Clonality
Monoclonal
Clone
ZAP70/2035
Applications
FACS, IF, ELISA, IHC
Components
Storage Conditions
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.
Applications Notes
Isotype
Mouse IgG1, kappa
Frequently Asked Questions
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