GSK-7975A

GSK-7975A is a potent and orally available CRAC channel inhibitor.

Product Specifications

CAS Number

[1253186-56-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Calcium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/GSK-7975A.html

Concentration

10mM

Purity

99.83

Solubility

DMSO : ≥ 90 mg/mL

Smiles

O=C(NC1=NN(CC2=CC=C(O)C=C2C(F)(F)F)C=C1)C3=C(F)C=CC=C3F

Molecular Formula

C18H12F5N3O2

Molecular Weight

397.30

Precautions

H302, H315, H319, H335

References & Citations

[1]Ashmole I, et al. CRACM/Orai ion channel expression and function in human lung mast cells. J Allergy Clin Immunol. 2012 Jun;129 (6) :1628-35.e2.|[2]Rice LV, et al. Characterization of selective Calcium-Release Activated Calcium channel blockers in mast cells and T-cells from human, rat, mouse and guinea-pig preparations. Eur J Pharmacol. 2013 Mar 15;704 (1-3) :49-57.|[3]Wen L, et al. Inhibitors of ORAI1 Prevent Cytosolic Calcium-Associated Injury of Human Pancreatic Acinar Cells and Acute Pancreatitis in 3 Mouse Models. Gastroenterology. 2015 Aug;149 (2) :481-92.e7.