Anti-STAT2 Monoclonal Antibody (Clone: STAT2/2650)

Membrane receptor signaling by various ligands, including interferons and growth hormones such as EGF, induces activation of JAK kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN- is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 has been shown to be activated by prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.

Product Specifications

Product Name Alternative

Homo sapiens interferon alpha induced transcriptional activator; interferon alpha induced transcriptional activator (ISGF3) ; P113; signal transducer and activator of transcription 2 113kD (STAT113) ; Signal transducer and activator of transcription 2 (STAT2)

Gene Name

STAT2

Gene ID

6773

UniProt

P52630

Host

Mouse

Reactivity

Human

Immunogen

Recombinant full-length human STAT2 protein

Clonality

Monoclonal

Clone

STAT2/2650

Applications

IHC

Components

200 μg/mL of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/mL.

Storage Conditions

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.

Applications Notes

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 min at RT) (Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95&degC followed by cooling at RT for 20 minutes)