Anti-RET Proto-oncogene Monoclonal Antibody (Clone: RET/2795)

The Ret proto-oncogene is structurally related to the growing family of tyrosine kinase transmembrane receptors and is involved in GDNF signaling. RET expression is reported in several regions of the central nervous system; in the developing cranial nerve ganglia and a subset of cells within dorsal root ganglia, in motor neurons in the spinal cord and hindbrain, in neuro-retina and the growing tips of the renal collecting ducts in developing kidney.Alterations in RETgene are associated with diseases including papillary thyroid carcinoma, multiple endocrine neoplasia (type 2A and 2B), familial medullary thyroid carcinoma, and a congenital developmental disorder known as Hirschsprung's disease.

Product Specifications

Product Name Alternative

Cadherin family member 12 (CDHF12) ; Cadherin related family member 16 (CDHR16) ; ELKS; HSCR1; Hydroxyaryl protein kinase; MEN2A; MEN2B; MTC1; Multiple endocrine neoplasia and medullary thyroid carcinoma 1; Oncogene RET; Proto-oncogene c-Ret; Proto-oncogene tyrosine-protein kinase receptor ret; PTC; R

Gene Name

RET

Gene ID

5979

UniProt

P07949

Host

Mouse

Reactivity

Human

Immunogen

Recombinant fragment (around aa 702-848) of human RET protein (exact sequence is proprietary)

Clonality

Monoclonal

Clone

RET/2795

Applications

IHC

Components

200 μg/mL of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/mL.

Storage Conditions

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.

Applications Notes

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)