Anti-Cyclin D1 (G1-Cyclin & Mantle Cell Lymphoma Marker) Monoclonal Antibody (Clone: CCND1/2593)
Selected Variant
36-3088-100
Size: 100 µg
Recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t (11; 14) (q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative) . Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.
Product Specifications
Product Name Alternative
Gene Name
CCND1
Gene ID
595
UniProt
P24385
Host
Mouse
Reactivity
Human
Immunogen
Recombinant full-length human CCND1 protein
Clonality
Monoclonal
Clone
CCND1/2593
Applications
IHC
Components
Storage Conditions
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.
Applications Notes
Isotype
Mouse IgG1, kappa
Price
Frequently Asked Questions
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