Anti-DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) Monoclonal Antibody (Clone: DG1/1484)
Selected Variant
36-2987-100
Size: 100 µg
Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GIST's), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GIST's, including all c-kit negative GIST's. Overexpression of DOG-1 has been sμggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GIST's is nearly identical: 94.4% vs. 94.7%.
Product Specifications
Product Name Alternative
Anoctamin 1; Calcium Activated Chloride Channel; Discovered On Gastrointestinal Stromal Tumors Protein 1; TAOS2; ORAOV2; TMEM16A
Gene Name
TMEM16A
Gene ID
55107
UniProt
Q5XX6
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human DOG-1 protein fragment (aa 2-101) (exact sequence is proprietary)
Clonality
Monoclonal
Clone
DG1/1484
Applications
IHC
Components
Storage Conditions
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.
Applications Notes
Isotype
Mouse IgG2b, kappa
Price
Frequently Asked Questions
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