Anti-Plakophilin-1 (PKP1) Monoclonal Antibody (Clone: 10B2)
Recognizes a protein of 75kDa, identified as Plakophilin-1. Its epitope maps between aa 1-27 human Plakophilin-1. Plakophilins 1, 2, 3 and 4 (PKP1-4) influence development and participate in linking cadherins to cytoskeletal intermediate filaments. Plakophilins 1-4 contain arm-repeat (armadillo) domains and localize to nuclei and cell desmosomes (cell-cell junctions found in suprabasal layers of stratifying epithelia that undergo mechanical stress) . Plakophilin 2 is important for desmosome assembly and is an essential morphogenic factor and architectural component of the heart.
Product Specifications
Product Name Alternative
B6P; Band 6 protein; PKP1; Plakophilin-1 (ectodermal dysplasia/skin fragility syndrome)
Gene Name
PKP1
Gene ID
5317
UniProt
Q13835
Host
Mouse
Reactivity
Human, Mouse
Immunogen
N-terminus of human Plakophilin-1 protein
Clonality
Monoclonal
Clone
10B2
Applications
FACS, IF, WB
Components
Storage Conditions
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.
Applications Notes
Flow Cytometry (1-2ug/million cells) ; Immunofluorescence (1-2ug/ml) ; Western Blot (1-2ug/ml)
Isotype
Mouse IgG1, kappa
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