Anti-Langerin / CD207 (Marker of Langerhans Cells) Monoclonal Antibody (Clone: rLGRN/1821)
Selected Variant
36-2889-20
Size: 20 µg
Langerhans cells (LCs) are a subset of immature dendritic cells (DCs) that specifically localize in the epidermis and other mucosal epithelia. Epidermal LCs possess strong immuno-stimulatory capacity and play a central role in the initiation and regulation of immune responses. Langerin (CD207) is a Ca2+-dependent, C-type lectin domain containing, type II transmembrane protein that induces epidermal LCs to differentiate into Birbeck granules (BG) . BGs are organelles with superimposing and zippering membranes that influence proper class I type antigen presentation to the circulating T cells. Human spleen, lymph node, thymus, liver, lung and heart express Langerin protein.
Product Specifications
Product Name Alternative
C-type lectin domain family 4 member K; CD207; CLEC4K; Langerhans cell specific c type lectin; Langerin
Gene Name
CD207
Gene ID
50489
UniProt
Q9UJ71
Host
Mouse
Reactivity
Human
Immunogen
Recombinant fragment (around aa74-213) of human Langerin protein (exact sequence is proprietary)
Clonality
Monoclonal
Clone
RLGRN/1821
Applications
ELISA
Components
Storage Conditions
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.
Applications Notes
ELISA (Use Ab at 2-4ug/ml for coating) (Order Ab without BSA)
Isotype
Mouse IgG1, kappa
Price
Frequently Asked Questions
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