Anti-NKX2.2 (Neuroendocrine & Ewing's Sarcoma Marker) Monoclonal Antibody (Clone: NX2/1524)
Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. It acts as a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential diagnosis of small round cell tumors.
Product Specifications
Product Name Alternative
Homeobox protein NK-2 homolog B, NK2 transcription factor like protein B, NK2 transcription factor related locus 2, NKX22, Nkx2b, tinman
Gene Name
NKX2-2
Gene ID
4821
UniProt
O95096
Host
Mouse
Reactivity
Human
Immunogen
Recombinant fragment (around aa1-119) of human NKX2.2 protein (exact sequence is proprietary)
Clonality
Monoclonal
Clone
NX2/1524
Applications
FACS, IF, IHC
Components
Storage Conditions
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.
Applications Notes
Isotype
Mouse IgG1, kappa
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Human IgG4 (Ig Heavy Constant Gamma 4) (G4m Marker) (IGHG4/2042R), CF640R conjugate, 0.1mg/mL
Major Vault Protein (MVP) (1014), CF594 conjugate, 0.1mg/mL
Cytokeratin 19 (A53-B/A2.26), CF488A conjugate, 0.1mg/mL
