Anti-CD137 / 4-1BB / TNFRSF9 Monoclonal Antibody (Clone: 4-1BB/3201)

CD137 belongs to the tumor necrosis factor receptor family and delivers a costimulatory signal to T lymphocytes. It is expressed on activated T cells and binds an inducible ligand that is found on B cells, macrophages and dendritic cells. Interactions between CD137 and its ligand are involved in antigen presentation and the generation of cytotoxic T cells. CD137 antibody may improve cancer treatment, and has been implicated in breast cancer, melanoma and lymphoma.

Product Specifications

Product Name Alternative

4-1BB Ligand Receptor T Cell; Antigen 4-1BB Homolog; CDw137; HLDA VI; Homolog of Mouse 4 1BB; induced by lymphocyte activation (ILA) ; Interleukin activated receptor homolog of Mouse Ly63; T-cell antigen 4-1BB / ILA homolog; Tumor necrosis factor receptor superfamily member 9

Gene Name

TNFRSF9

Gene ID

3604

UniProt

Q07011

Host

Mouse

Reactivity

Human

Immunogen

A recombinant fragment (around aa 19-188) of human CD137 / 4-1BB / TNFRSF9 protein (exact sequence is proprietary)

Clonality

Monoclonal

Clone

4-1BB/3201

Applications

ELISA, IF, FACS, WB, IHC

Components

200 μg/mL of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/mL.

Storage Conditions

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.

Applications Notes

ELISA (For coating, order antibody without BSA) ; , Immunofluorescence (1-2ug/ml) ; Flow Cytometry (1-2ug/million cells) ; Western Blot (1-2ug/ml) ; Immunohistochemistry (Formalin-fixed) (2-4ug/ml for 30 minutes at RT), (Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 &degC followed by cooling at RT for 20 minutes)