Anti-Lambda Light Chain (B-Cell Marker) Monoclonal Antibody (Clone: N10/2)
This MAb is specific to lambda light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of Kappa to Lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the lambda light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.
Product Specifications
Product Name Alternative
Bence Jones Protein; BJP; IGLC 1/2/3; Mcg Marker; Paraprotein
Gene Name
IGL
Gene ID
3535; 3546
UniProt
P01701; P01842
Host
Mouse
Reactivity
Human
Immunogen
Purified IgG from human serum
Clonality
Monoclonal
Clone
N10/2
Applications
FACS, IF, WB, IHC
Components
Storage Conditions
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.
Applications Notes
Isotype
Mouse IgG1, kappa
Frequently Asked Questions
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