Anti-Insulin-like Growth Factor-1 (IGF-1) Monoclonal Antibody (Clone: SPM406)

This antibody is specific to Insulin-like Growth Factor (IGF-1) and shows minimal cross-reaction with IGF-11, Proinsulin, MSF, and Insulin. IGF-1 is a polypeptide growth factor with two isoforms that are produced by alternative splicing. Isoform 1 is also known as IGF-IB while isoform 2 is known as IGF-IA. IGF-1 stimulates the proliferation of a wide range of cell types including muscle, bone and cartilage tissue. It functions as an autocrine regulator of growth. Activation of IGF system has emerged as a key factor for tumor progression and resistance to apoptosis in many cancers like those of breast, thyroid and colon.

Product Specifications

Product Name Alternative

Insulin-like Growth Factor IA (IGF-IA) ; Insulin-like Growth Factor IB (IGF-IB) ; Mechano Growth Factor (MGF) ; Somatomedin-C

Gene Name

IGF1

Gene ID

3479

UniProt

P05019

Host

Mouse

Reactivity

Human, Mouse, Rat

Immunogen

Purified human IGF-1 protein

Clonality

Monoclonal

Clone

SPM406

Applications

ELISA, FACS, IF, IHC

Components

200 μg/mL of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/mL.

Storage Conditions

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.

Applications Notes

ELISA (For coating, purchase antibody without BSA) ; Flow Cytometry (1-2ug/million cells) ; Immunofluorescence (1-2ug/ml) ; Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 min at RT) ; In-vitro Neutralization of Biological Activity of IGF-1 (Order Ab without Azide)