Anti-Serum Amyloid P / APCS Monoclonal Antibody (Clone: APCS/3240)

Serum amyloid P (SAP) is a glycoprotein belonging to the pentraxin family of proteins, which has a characteristic pentameric organization and calciumdependent ligand binding. Secreted by liver epithelial cells, SAP is found in serum and urine. Althoμgh the function of SAP has not been clearly established, it has been shown to interact with DNA and histones and is thoμght to play a role in scavenging nuclear material released from damaged circulating cells. Also designated PTX2, SAP is a precursor of the protein amyloid P component (AP), which is universally associated with the amyloid deposits in all forms of amyloidoses, including Alzheimer s disease. SAP is a decamer of ten identical, noncovalently linked subunits, each of which may be post-translationally modified by glycosylation.

Product Specifications

Product Name Alternative

9.5S alpha 1 glycoprotein; Amyloid P component serum (APCS) ; Pentaxin related; Pentraxin 2 (PTX2) ; Serum Amyloid P (SAP) ; Serum amyloid P component

Gene Name

APCS

Gene ID

325

UniProt

P02743

Host

Mouse

Reactivity

Human

Immunogen

Recombinant fragment of human APCS protein (around aa 143-223) (exact sequence is proprietary)

Clonality

Monoclonal

Clone

APCS/3240

Applications

IHC

Components

200 μg/mL of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/mL.

Storage Conditions

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.

Applications Notes

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT), (Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95&degC followed by cooling at RT for 20 minutes)