Anti-HLA-DRB (MHC II) Monoclonal Antibody (Clone: Bra30)

This MAb reacts with the HLA-DRB3 antigen, a member of MHC class II molecules.It does not cross react with HLA-DP and HLA-DQ. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36kDa alpha (heavy) chain and a 28kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts.

Product Specifications

Product Name Alternative

HLA class II histocompatibility antigen DR beta 3 chain; HLADR3B; Major histocompatibility complex, class II DR beta 3

Gene Name

HLA-DRB3

Gene ID

3123

UniProt

P01911

Host

Mouse

Reactivity

Human

Immunogen

Human REH cells (non-T, non-B leukemia cell line)

Clonality

Monoclonal

Clone

Bra30

Applications

FACS, IF

Components

200 μg/mL of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/mL.