Anti-HLA-DRB (MHC II) Monoclonal Antibody (Clone: Bra30)
This MAb reacts with the HLA-DRB3 antigen, a member of MHC class II molecules.It does not cross react with HLA-DP and HLA-DQ. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36kDa alpha (heavy) chain and a 28kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts.
Product Specifications
Product Name Alternative
HLA class II histocompatibility antigen DR beta 3 chain; HLADR3B; Major histocompatibility complex, class II DR beta 3
Gene Name
HLA-DRB3
Gene ID
3123
UniProt
P01911
Host
Mouse
Reactivity
Human
Immunogen
Human REH cells (non-T, non-B leukemia cell line)
Clonality
Monoclonal
Clone
Bra30
Applications
FACS, IF
Components
Storage Conditions
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.
Applications Notes
Flow Cytometry (1-2ug/million cells) ; Immunofluorescence (1-2ug/ml)
Isotype
Mouse IgG2a, kappa
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