Anti-HLA-ABC (MHC I) Monoclonal Antibody (Clone: 246-B8.E7)

Reacts with a monomorphic determinant of human major histocompatibility (MHC) class I antigens (HLA-A, B and C) . Human MHC class I antigens are expressed constitutively on all nucleated cells lymphocytes such as lymphocytes, thymocytes, granulocytes, and bone marrow cells and are absent on erythrocytes. MHC class I antigens play a role in class I MHC-associated antigen presentation, inhibition of NK cell cytotoxicity, tumor surveillance, and tissue allotransplantation.

Product Specifications

Product Name Alternative

HLA-A; HLA-B; HLA-C; HLA class 1A; HLA class 1B; HLA class 1C; Major histocompatibility complex, class I, A + B + C; MHC class I HLA-A; MHC class I HLA-B; MHC class I HLA-C; MHC HLA-ABC

Gene Name

HLA-A; HLA-B; HLA-C

Gene ID

3105; 3106; 3107

UniProt

P01889; P30443; P30499

Host

Mouse

Reactivity

Human, Mouse

Immunogen

Human peripheral blood leukocytes

Clonality

Monoclonal

Clone

246-B8.E7

Applications

FACS, IF

Components

200 μg/mL of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/mL.