Gosogliptin
Gosogliptin is a potent and selective inhibitor of dipeptidyl peptidase-IV (DPP-IV) .
Product Specifications
CAS Number
[869490-23-3]
Product Name Alternative
PF-00734200; PF-734200
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Dipeptidyl Peptidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Gosogliptin.html
Purity
99.83
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C([C@H](C1)NC[C@H]1N2CCN(CC2)C3=NC=CC=N3)N4CC(CC4)(F)F
Molecular Formula
C17H24F2N6O
Molecular Weight
366.41
Precautions
H302, H315, H319, H335
References & Citations
[1]Dai H, et al. The pharmacokinetics of PF-734200, a DPP-IV inhibitor, in subjects with renal insufficiency. Br J Clin Pharmacol. 2011 Jul;72 (1) :85-91.|[2]Sharma R, et al. Metabolism, excretion, and pharmacokinetics of ((3,3-difluoropyrrolidin-1-yl) ((2S,4S) -4- (4- (pyrimidin-2-yl) piperazin-1-yl) pyrrolidin-2-yl) methanone, a dipeptidyl peptidase inhibitor, in rat, dog and human. Drug Metab Dispos. 2012 Nov;40 (11) :2143-61.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
DPP-4
Available Sizes
Curated Selection
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