Anti-NKX2.8 Monoclonal Antibody (Clone: NKX28/2548)
The protein encoded by this gene is a homeobox-containing developmental regulator associated with liver development. The encoded protein binds to the alpha-fetoprotein (AFP) gene promoter and increases the expression of AFP. This gene is overexpressed in some lung cancers and is linked to poor patient survival, possibly due to its resistance to cisplatin. This gene is aberrantly methylated in pancreatic cancer, deleted in squamous cell lung carcinomas, and acts as a tumor suppressor in esophageal cancer. Mutations in this gene may also be a cause of neural tube defects.
Product Specifications
Product Name Alternative
Gene Name
NKX2-8
Gene ID
26257
UniProt
O15522
Host
Mouse
Reactivity
Human
Immunogen
Human recombinant NKX2.8 protein fragment (around aa 10-123) (exact sequence is proprietary)
Clonality
Monoclonal
Clone
NKX28/2548
Applications
WB, ELISA, FACS, WB
Components
Storage Conditions
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.
Applications Notes
Western Blot (2-4ug/ml) ; ELISA (For coating, order antibody without BSA) ; Flow Cytometry (1-2ug/million cells) ; Western Blot (1-2ug/ml)
Isotype
Mouse IgG1, kappa
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