Anti-FOLH1 / PSMA (Prostate Epithelial Marker) Monoclonal Antibody (Clone: SPM500)

Folate hydrolase 1 (FOLH1), also known as Prostate-specific membrane antigen (PSMA), is a type II transmembrane glycoprotein belonging to the M28 peptidase family. FOLH1 has two enzymatic activities, one as a prostate-specific integral membrane folate hydrolase and the other as a carboxypeptidase In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer.

Product Specifications

Product Name Alternative

Cell growth-inhibiting gene 27 protein (GIG27) ; Folate hydrolase 1 (FOLH1) ; Folylpoly-gamma-glutamate carboxypeptidase (FGCP) ; Glutamate carboxylase II (GCPII) ; Glutamate carboxypeptidase 2 (GCP2) ; Glutamate carboxypeptidase II Membrane glutamate carboxypeptidase N-acetylated-alpha-linked acidic dip

Gene Name

FOLH1

Gene ID

2346

UniProt

Q04609

Host

Mouse

Reactivity

Human

Immunogen

Recombinant human FOLH1 protein fragment (around aa 232-433) (exact sequence is proprietary)

Clonality

Monoclonal

Clone

SPM500

Applications

WB, IHC

Components

200 μg/mL of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/mL.

Storage Conditions

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.

Applications Notes

Western Blot (1-2ug/ml) ; Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95&degC followed by cooling at RT for 20 minutes)