Anti-ERCC1 / RAD10 (Tumor Progression Marker) Monoclonal Antibody (Clone: ERCC1/2318)
Recognizes a protein of 110kDa, identified as Excision Repair Cross Complementing 1 (ERCC1) . It is a mammalian nucleotide excision repair (NER) enzyme involved in repair of damaged DNA. ERCC1 is a homologous to RAD10 in Saccharomyces cerevisiae, which is required in mitotic intrachromosomal recombination and repair. ERCC1 is required in repair of cisplatin-induced DNA adducts and ultraviolet (UV) -induced DNA damage. High expression of ERCC1 has been linked to tumor progression in a variety of cancers including non-small cell lung cancer (NSCLC), squamous cell carcinoma of the head, ovarian cancer and esophageal cancer.
Product Specifications
Product Name Alternative
COFS4; DNA excision repair protein ERCC1; ERCC1; Excision repair cross complementing 1; RAD10; UV20
Gene Name
ERCC1
Gene ID
2067
UniProt
P07992
Host
Mouse
Reactivity
Human
Immunogen
Recombinant fragment (around aa 191-281) of human ERCC1 protein (exact sequence is proprietary)
Clonality
Monoclonal
Clone
ERCC1/2318
Applications
ELISA, WB
Components
Storage Conditions
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.
Applications Notes
ELISA (For coating, order antibody without BSA) ; Western Blot (1-2ug/ml)
Isotype
Mouse IgG2b, kappa
Frequently Asked Questions
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