Anti-HER-2 / c-erbB-2 / neu / CD340 Monoclonal Antibody (Clone: HRB2/258)
Recognizes a protein of 185kDa, which is identified as c-erbB-2/HER-2/neu. Its epitope is localized in the extracellular domain. C-erbB-2/HER-2 is a member of the EGFR family. This MAb is specific and shows minimal cross-reaction with other members of the EGFR-family. Receptors of this family are located on the plasma membrane and consist of an extracellular ligand-binding domain that is connected to a large intracellular domain by a single transmembrane sequence. C-erbB-2/HER-2 protein is over-expressed in a variety of carcinomas especially those of breast and ovary.
Product Specifications
Product Name Alternative
P185, Verb b2 Erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/Glioblastoma Derived Oncogene Homolog
Gene Name
ERBB2
Gene ID
2064
UniProt
P04626
Host
Mouse
Reactivity
Human, rat
Immunogen
Recombinant extracellular domain of human HER-2 protein
Clonality
Monoclonal
Clone
HRB2/258
Applications
ELISA, FACS, IF
Components
Storage Conditions
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.
Applications Notes
ELISA (For coating, order antibody without BSA) ; , Flow Cytometry (1-2ug/million cells) ; , Immunofluorescence (1-2ug/ml) ;
Isotype
Mouse IgG2a, kappa
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