Anti-EGFR (Epidermal Growth Factor Receptor) Monoclonal Antibody (Clone: F4)
This MAb recognizes a protein of 170kDa, identified as EGFR. EGFR is type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-alphaa), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.
Product Specifications
Product Name Alternative
ERBB1; HER1; mENA; PIG61; Proto-oncogene c-ErbB-1; Receptor Tyrosine Protein Kinase; ErbB1; Urogastrone
Gene Name
EGFR
Gene ID
1956
UniProt
P00533
Host
Mouse
Reactivity
Human
Immunogen
A synthetic peptide corresponding to aa 985-996 of human EGFR
Clonality
Monoclonal
Clone
F4
Applications
WB
Components
Storage Conditions
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.
Applications Notes
Western Blot (1-2ug/ml)
Isotype
Mouse IgG1, kappa
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