Anti-EGFR (Epidermal Growth Factor Receptor) Monoclonal Antibody (Clone: GFR450) -CF488
This MAb recognizes a protein of 170kDa, identified as EGFR. EGFR is type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-alphaa), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.
Product Specifications
Product Name Alternative
Erbb1; ERBB1; Errp; HER1; mENA; PIG61; Proto-oncogene c-ErbB-1; Receptor Tyrosine Protein Kinase; ErbB1; Urogastrone; wa2; Wa5
Gene Name
EGFR
Gene ID
1956
UniProt
P00533
Host
Mouse
Reactivity
Human
Immunogen
Recombinant extracellular domain of human EGFR protein
Clonality
Monoclonal
Clone
GFR450
Applications
FACS, IF
Components
Storage Conditions
Antibody with azide - store at 4 to 8°C. Antibody is stable for 24 months. Non-hazardous.
Applications Notes
Flow Cytometry (5ul per test per one million cells or 5ul per 100ul of whole blood) ; Immunofluorescence (1:50-1:100)
Isotype
Mouse IgG2a, kappa
Conjugate
CF488
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