Anti-Desmoglein-3 (Squamous Cell Marker) Monoclonal Antibody (Clone: DSG3/2796)
Recognizes a protein of 130kDa, identified as Desmoglein-3 (DSG3) . This MAb is highly specific to Desmoglein-3 and does not cross-react with other members of the Desmoglein-family. DSG3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Research has shown that DSG3 has a very high sensitivity (80%) and specificity (100%) in recognizing squamous cell carcinoma (SqCC) . Therefore, DSG3 is considered a very important marker for lung SqCC and can be a useful ancillary marker to separate SqCC from other subtypes of lung cancer. Moreover, studies have shown that DSG3 expression in lung SqCC may indicate a poor prognosis.
Product Specifications
Product Name Alternative
130kDa pemphigus vulgaris antigen (PVA) ; Balding (Bal) ; Cadherin family member 6 (CDHF6) ; Desmoglein-3 (DSG3)
Gene Name
DSG3
Gene ID
1830
UniProt
P32926
Host
Mouse
Reactivity
Human
Immunogen
Recombinant fragment (around aa 379-491) human DSG3 protein (exact sequence is proprietary)
Clonality
Monoclonal
Clone
DSG3/2796
Applications
ELISA, WB
Components
Storage Conditions
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.
Applications Notes
ELISA (For coating, order Ab without BSA) ; Western Blot (1-2ug/ml)
Isotype
Mouse IgG2b, kappa
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