Anti-Desmoglein-3 (Squamous Cell Marker) Monoclonal Antibody (Clone: 5H10)
Recognizes a protein of 130kDa, identified as Desmoglein-3 (DSG3) . This MAb is highly specific to Desmoglein-3 and does not cross-react with other members of the Desmoglein-family. DSG3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Currently, three desmoglein subfamily members are identified and all are members of the cadherin cell adhesion molecule superfamily.
Product Specifications
Product Name Alternative
130kDa pemphigus vulgaris antigen (PVA) ; Balding (Bal) ; Cadherin family member 6 (CDHF6) ; Desmoglein-3 (DSG3)
Gene Name
DSG3
Gene ID
1830
UniProt
P32926
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human DSG3 extracellular protein fragment
Clonality
Monoclonal
Clone
5H10
Applications
FACS, IF, WB
Components
Storage Conditions
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.
Applications Notes
Flow Cytometry (1-2ug/million cells) ; Immunofluorescence (1-2ug/ml) ; Western Blot (1-2ug/ml)
Isotype
Mouse IgG1, kappa
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