Monoclonal Antibody to CD269 / TNFRSF17 / BCMA (B-Cell Maturation Protein) (MHC II) (Clone : BCMA/2366)

The B cell maturation protein (BCMA) is a type I integral membrane protein that belongs to the tumor necrosis factor receptor (TNF-alpha) superfamily. It is expressed as a 184 amino acid peptide that is expressed only in mature B-lymphocytes and is located on the cis part of the Golgi apparatus. BCMA shares significant homology with TACI (transmembrane activator) within the cysteine-rich domain. TACI has been shown to bind CAML, which induces activation of NFAT (nuclear factor of activated T cells) . Both BCMA and TACI have been shown to bind APRIL and TALL-1, which stimulate B cell proliferation in conjunction with other B-cell activators. When overexpressed, TALL-1 stimulates the development of systemic lupus erythaematosus (SLE) .

Product Specifications

Product Name Alternative

B-cell maturation protein; BCMA; CD269; TNR17; Tumor necrosis factor receptor superfamily member 17 (TNFRSF17)

Gene Name

CD269

Gene ID

608

UniProt

Q02223

Host

Mouse

Reactivity

Human

Immunogen

Recombinant human CD269 protein fragment (around aa 78-184) (exact sequence is proprietary)

Clonality

Monoclonal

Clone

BCMA/2366

Applications

ELISA, IHC

Purification

Affinity Chromatography

Components

Purified Ab with BSA and Azide at 200ug/mL

Storage Conditions

Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C.

Applications Notes

ELISA (For coating, order antibody without BSA) ; , Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT), (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.