Monoclonal Antibody to CD27 (Tumor Necrosis Factor Receptor Superfamily 7) (Clone : 203.6)
Recognizes a protein of a disulfide-linked 120kDa dimer, identified as CD27 (Workshop VI; Code 6T-028) . CD27 is expressed on the majority of peripheral T cells, medullary thymocytes, memory-type B cells, and natural killer cells. It is a transmembrane phosphoglycoprotein that belongs to the tumor necrosis factor receptor (TNFR) superfamily. CD27 binds to its ligand CD70, a member of the TNF family, and induces T-cell co-stimulation and B-cell activation. It also interacts with TRAFs and is involved in activation of NFB and SAPK/JNK and induces apoptosis.
Product Specifications
Product Name Alternative
CD27||TNFRSF7
Gene Name
CD27
Gene ID
939
UniProt
P26842
Host
Mouse
Reactivity
Human
Immunogen
Sezary cells
Target Antigen
CD27 (Tumor Necrosis Factor Receptor Superfamily 7)
Clonality
Monoclonal
Clone
203.6
Applications
FACS, IF
Purification
Affinity Chromatography
Format
Purified
Components
100 μg in 500 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Flow Cytometry (1-2ug/million cells) ; , Immunofluorescence (1-2ug/ml) ;
Isotype
Mouse IgG3, kappa
Frequently Asked Questions
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