Monoclonal Antibody to CD22 / BL-CAM (Clone : FR10B4)
Recognizes a protein of 130-140kDa, identified as CD22 (also known as BL-CAM) . CD22 expression is restricted to normal and neoplastic B cells and is absent from other haemopoietic cell types. In B-cell ontogeny, CD22 is first expressed in the cytoplasm of pro-B and pre-B cells, and on the surface as B cells mature to become IgD+. It is not expressed by plasma cells, CD22 is found highly expressed in follicular mantle and marginal zone B-cells, and while germinal center B-cells are relatively weak. CD22 is a member of the immunoglobulin superfamily and serves as an adhesion receptor for sialic acid-bearing ligands expressed on erythrocytes and all leukocyte classes. It also associates with tyrosine kinases and play a role in signal transduction and B-cell activation.
Product Specifications
Product Name Alternative
CD22||SIGLEC2
Gene Name
CD22
Gene ID
933
UniProt
P20273
Host
Mouse
Reactivity
Human
Immunogen
Human Burkitt's lymphoma cells
Target Antigen
CD22 / BL-CAM
Clonality
Monoclonal
Clone
FR10B4
Applications
Functional Assay, FACS, IF
Purification
Affinity Chromatography
Format
Purified
Components
100 μg in 500 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Functional Studies (Order Ab without Azide) ; Flow Cytometry (1-2ug/million cells) ; Immunofluorescence (1-2ug/ml)
Isotype
Mouse IgG1, kappa
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