Monoclonal Antibody to CD20 / MS4A1 (B-Cell Marker) (Clone : 109-3C2)
Recognizes a protein of 30-33kDa, which is identified as CD20 (Workshop V; Code CD20.12. Workshop IV; Code B17) . It recognizes an extracellular domain of CD20. It is a non-Ig differentiation antigen of B-cells and its expression is restricted to normal and neoplastic B-cells, being absent from all other leukocytes and tissues. CD20 is expressed by pre B-cells and persists during all stages of B-cell maturation but is lost upon terminal differentiation into plasma cells. The protein passes through the membrane 4 times with both ends in cytoplasm and exposes one short and one longer loop to the external environment. CD20 is not glycosylated in resting B-cells and its cytoplasmic domains are differentially phosphorylated upon activation. It acts as calcium channel involved in B cell activation and cell cycle progression.
Product Specifications
Product Name Alternative
MS4A1||CD20
Gene Name
MS4A1
Gene ID
931
UniProt
P11836
Host
Mouse
Reactivity
Human
Immunogen
Stimulated human leukocytes
Target Antigen
CD20 / MS4A1 (B-Cell Marker)
Clonality
Monoclonal
Clone
109-3C2
Applications
Functional Assay, Azide, ELISA
Purification
Affinity Chromatography
Format
Purified
Components
100 μg in 500 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Functional Studies (Order Ab without BSA & Azide) ; , ELISA (For coating, order antibody without BSA) ;
Isotype
Mouse IgG3, kappa
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