Monoclonal Antibody to CD6 (Clone : 3F7B5)
CD6 is a type I transmembrane glycoprotein that contains a 24-amino acid signal sequence, three extracellular scavenger receptor cysteine-rich (SRCR) domains, a membrane-spanning domain and a 44-amino acid cytoplasmic domain. The CD6 glycoprotein is tyrosine phosphorylated during TCR-mediated T cell activation. CD6 shows significant homology to CD5. CD6 is present on mature thymocytes, peripheral T cells and a subset of B cells. Antibodies to CD6 are used to deplete T cells from bone marrow transplants to prevent graft versus host disease.
Product Specifications
Product Name Alternative
CD6
Gene Name
CD6
Gene ID
923
UniProt
P30203
Host
Mouse
Reactivity
Human
Immunogen
Human rheumatoid synovial T cell line ST-1
Target Antigen
CD6
Clonality
Monoclonal
Clone
3F7B5
Applications
FACS, IF, IHC
Purification
Affinity Chromatography
Format
Purified
Components
100 μg in 500 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Isotype
Mouse IgG1, kappa
Frequently Asked Questions
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